Dr. Christopher Lawrence, BSc MBBS LLM MD(Res) MRCP(nephrology) FRCP
Director of Medical Affairs,
Thermo Fisher Scientific
Speaker
Gaurav Gupta
Medical Director of the Kidney Transplant Program
Virginia Commonwealth University
Richmond, VA
Learning Objectives:
- Recognize the significance of molecular diagnostic methods in kidney transplantation
- Understand the complementary diagnostic value of gene expression in kidney transplant biopsies in addition to traditional histology
- Understand how to incorporate the molecular microscope results into a management plan
Personalized Transplant Care Through Precision Medicine
One Lambda is dedicated to enabling more personalized treatment in the transplant clinic in order to help our customers improve the lives of patients around the world.
Our comprehensive product portfolio includes a broad range of Antibody Detection assays, HLA Typing products, and post-transplant monitoring solutions, including MMDx® Heart and MMDx® Kidney for gene expression profiling of transplant biopsies.
On-Demand Symposia
ISHLT 2021
Innovations in Rejection Surveillance after Heart Transplantation
Moderator:
Dr. Christopher Lawrence, BSc MBBS LLM MD(Res) MRCP(nephrology) FRCP
Director of Medical Affairs | Thermo Fisher Scientific
Guest Speaker:
Jon A. Kobashigawa, MD │ Director, Heart Transplant Program │Cedars-Sinai Medical Center, Los Angeles, California
For post-transplant management in heart patients, the endomyocardial biopsy is considered the gold standard to detect acute rejection. However, research has found that in biopsy assessments for rejection, concordance among expert pathologists is less than 67%. This presentation will explore case studies and the clinical use of novel technologies, including molecular diagnostic testing of intragraft mRNA transcripts and donor-derived cell-free DNA, for more accurate diagnosis of cellular and antibody-mediated rejection, acute rejection, and cardiac allograft vasculopathy (CAV).
ATC 2021
Clinical Applications for MMDx®: Gene Expression Profiling in Transplant Biopsies
Moderator:
Dr. Christopher Lawrence, BSc MBBS LLM MD(Res) MRCP(nephrology) FRCP
Director of Medical Affairs | Thermo Fisher Scientific
Guest Speakers:
- Georg Böhmig, MD | Medical University of Vienna – Vienna, Austria
- Gaurav Gupta, MD | Virginia Commonwealth University – Richmond, VA
- Divya Raghavan, MD | University of Utah Medical Group – Salt Lake City, UT
With a future effective LCD announced for molecular testing for solid organ allograft rejection, clinicians may now consider applying molecular gene expression profiling in a variety of clinical cases. This presentation will explore the use of the Molecular Microscope® Diagnostic System for the management of post-transplant kidney and heart patients. The speakers will discuss a variety of case studies where molecular assessment was applied to diagnose allograft dysfunction and to determine if rejection was due to antibody-mediated rejection (ABMR), T-cell-mediated rejection (TCMR), or a combination of both.
Case Study
Read the full case study titled "A Challenging Diagnosis in Kidney Transplantation: A case study on how the Molecular Microscope provides added confidence and alters management" at: go.1lambda.com/video-rgvn2021
Publication Summary
