Meet the One Lambda Brand: Delivering Personalized Transplant Care Through Precision

For over 25 years, One Lambda brand assays have been the gold standard for the detection of donor-specific antibodies. As the trusted partner of HLA labs around the world, we provide essential assays to deliver reliable and actionable data for the screening and monitoring of transplant patients. In this short video, discover how we are working to help deliver personalized care to every transplant patient.

Webinar:

Using Molecular Diagnostics for Kidney Transplants: Getting There!

Watch the webinar

This presentation focused on the use of gene expression profiling for the management of kidney transplant biopsies.

Speaker

Gaurav Gupta, MD

Gaurav Gupta

Medical Director of the Kidney Transplant Program

Virginia Commonwealth University

Richmond, VA

Learning Objectives:

  • Recognize the significance of molecular diagnostic methods in kidney transplantation
  • Understand the complementary diagnostic value of gene expression in kidney transplant biopsies in addition to traditional histology
  • Understand how to incorporate the molecular microscope results into a management plan

Personalized Transplant Care Through Precision Medicine

One Lambda is dedicated to enabling more personalized treatment in the transplant clinic in order to help our customers improve the lives of patients around the world.

Our comprehensive product portfolio includes a broad range of Antibody Detection assays, HLA Typing products, and post-transplant monitoring solutions, including MMDx® Heart and MMDx® Kidney for gene expression profiling of transplant biopsies.

On-Demand Symposia

ISHLT 2021
Innovations in Rejection Surveillance after Heart Transplantation

Moderator:
Dr. Christopher Lawrence, BSc MBBS LLM MD(Res) MRCP(nephrology) FRCP
Director of Medical Affairs | Thermo Fisher Scientific

Guest Speaker:
Jon A. Kobashigawa, MD │ Director, Heart Transplant Program │Cedars-Sinai Medical Center, Los Angeles, California

For post-transplant management in heart patients, the endomyocardial biopsy is considered the gold standard to detect acute rejection. However, research has found that in biopsy assessments for rejection, concordance among expert pathologists is less than 67%. This presentation will explore case studies and the clinical use of novel technologies, including molecular diagnostic testing of intragraft mRNA transcripts and donor-derived cell-free DNA, for more accurate diagnosis of cellular and antibody-mediated rejection, acute rejection, and cardiac allograft vasculopathy (CAV).

ATC 2021
Clinical Applications for MMDx®: Gene Expression Profiling in Transplant Biopsies

Moderator:
Dr. Christopher Lawrence, BSc MBBS LLM MD(Res) MRCP(nephrology) FRCP
Director of Medical Affairs | Thermo Fisher Scientific

Guest Speakers:

  • Georg Böhmig, MD | Medical University of Vienna – Vienna, Austria
  • Gaurav Gupta, MD | Virginia Commonwealth University – Richmond, VA
  • Divya Raghavan, MD | University of Utah Medical Group – Salt Lake City, UT

With a future effective LCD announced for molecular testing for solid organ allograft rejection, clinicians may now consider applying molecular gene expression profiling in a variety of clinical cases. This presentation will explore the use of the Molecular Microscope® Diagnostic System for the management of post-transplant kidney and heart patients. The speakers will discuss a variety of case studies where molecular assessment was applied to diagnose allograft dysfunction and to determine if rejection was due to antibody-mediated rejection (ABMR), T-cell-mediated rejection (TCMR), or a combination of both.

Case Study

A Challenging Diagnosis in Kidney Transplantation: A case study on how the Molecular Microscope Diagnostic System for Kidney (MMDx Kidney) provides added confidence and alters management
Dr. Raghavan’s case study at 2021 ATC describes how MMDx Kidney can help in challenging kidney transplant diagnostics, how MMD Kidney reports were more consistent with the patient’s clinical course, and how they increased confidence in the patient management. We bring the full video case study as well as the written summary.

Read the full case study titled "A Challenging Diagnosis in Kidney Transplantation: A case study on how the Molecular Microscope provides added confidence and alters management" at: go.1lambda.com/video-rgvn2021

Publication Summary

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